AEROPATH Target Database
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Locus Tag (e.g. PA3724)
Gene Name (e.g. lasB)
Product name (e.g. elastase)
Is perturbative (i.e. is essential or virulence factor)
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Chemogenomic Druggability prediction
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Yes
No
Structure-based Druggability prediction
All
Yes
No
Human homologs
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Yes
No
Structure solved
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Yes
No
PDB homologs
All
Yes
No
Bacterial drug target
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Page 1 of 3, showing 25 records out of 53 total, starting on record 1, ending on 25
Locus tag
Gene name
Product name
ChEMBL homologs
Chemogenomic druggability rank
Mean QED
Structure-based druggability
Essentiality
Virulence Factor
Drug Target
Human homologs
Microbes havings orthologs
Structures solved
Structural homologs
XtalPred Class
PA0408
pilG
twitching motility protein PilG
5
470
0.68
-
E
YES
-
0
2/4
0
282
1
PA0409
pilH
twitching motility protein PilH
5
353
0.68
-
N
YES
-
0
2/4
0
309
1
PA0413
chpA
component of chemotactic signal trans...
6
355
0.68
-
N
YES
-
0
2/4
0
357
5
PA0555
fda
fructose-1,6-bisphosphate aldolase
6
560
0.17
-
E
-
-
0
3/4
0
71
2
PA0576
rpoD
sigma factor RpoD
1
147
0.06
-
E
-
-
0
4/4
0
51
5
PA0672
hemO
heme oxygenase
1
7
0.54
-
E
-
-
0
2/4
0
5
3
PA0928
gacS
sensor/response regulator hybrid
11
435
0.67
-
N
YES
-
0
4/4
0
257
5
PA1098
fleS
two-component sensor
5
866
0.54
-
N
YES
-
0
0/4
0
17
4
PA1099
fleR
two-component response regulator
5
379
0.68
-
N
YES
-
0
0/4
0
311
4
PA1430
lasR
transcriptional regulator LasR
4
8
0.68
mixed
N
YES
-
0
0/4
23
32
2
PA1455
fliA
sigma factor FliA
1
960
0.06
-
N
YES
-
0
2/4
0
31
2
PA1456
cheY
two-component response regulator CheY
5
329
0.68
-
E
-
-
0
2/4
0
269
1
PA1619
-
probable transcriptional regulator
1
661
0.21
-
E
-
-
0
2/4
0
7
5
PA1681
aroC
chorismate synthase
1
378
0.52
-
E
-
-
0
4/4
0
27
2
PA1713
exsA
transcriptional regulator ExsA
1
5
0.21
-
E
YES
-
0
1/4
0
1
4
PA1816
dnaQ
DNA polymerase III, epsilon chain
3
520
0.54
-
E
-
-
0
4/4
0
8
5
PA1882
-
probable transporter
2
99
0.54
-
E
-
-
0
2/4
0
16
5
PA1903
phzE2
phenazine biosynthesis protein PhzE
2
348
0.75
-
N
YES
-
0
0/4
0
46
4
PA2191
exoY
adenylate cyclase ExoY
1
614
0.57
-
N
YES
-
0
0/4
0
65
3
PA2192
-
conserved hypothetical protein
1
904
0.22
-
E
-
-
0
0/4
0
31
1
PA2586
gacA
response regulator GacA
4
752
0.25
-
N
YES
-
0
4/4
0
104
3
PA2798
-
probable two-component response regul...
4
518
0.68
-
E
-
-
0
3/4
12
351
4
PA2943
-
phospho-2-dehydro-3-deoxyheptonate al...
3
260
0.13
-
P
-
-
0
1/4
0
71
3
PA2977
murB
UDP-N-acetylpyruvoylglucosamine reduc...
2
359
0.28
-
E
-
-
0
4/4
0
10
2
PA3117
asd
aspartate semialdehyde dehydrogenase
1
903
0.31
-
E
-
-
0
3/4
0
52
2
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