AEROPATH Target Database
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P. aeruginosa genome

Size of P. aeruginosa genome
5,677
Number of protein coding genes
5,571

Druggability

Total number of ChEMBL homologs
10,592
Number of proteins having ChEMBL homologs
1,226
 
(22% of the proteome)
Number of proteins with druggability predictions
966
 
(17.3% of the proteome)

Perturbance

Number of virulence factors
252
 
(4.5% of the proteome)
Number of essential genes
773
 
(13.9% of the proteome)
Number of perturbative proteins
992
(i.e. essential or virulence factor)
(17.8% of the proteome)

Selectivity

Total number of human homologs
15,245
Number of proteins having human homologs
1,449
 
(26% of the proteome)
Total number of human orthologs
2,406
Number of proteins having human orthologs
805
 
(14.4% of the proteome)

Spectrum

Total number of microbial homologs
101,164
Number of proteins having microbial homologs
4,362
 
(78.3% of the proteome)
Total number of microbial orthologs
10,194
Number of proteins having microbial orthologs
3,608
 
(64.8% of the proteome)
Total number of A. baumanii homologs
18,664
Number of proteins having A. baumanii homologs
3,352
 
(60.2% of the proteome)
Total number of A. baumanii orthologs
2,447
Number of proteins having A. baumanii orthologs
2,155
 
(38.7% of the proteome)
Total number of E. coli homologs
23,380
Number of proteins having E. coli homologs
3,428
 
(61.5% of the proteome)
Total number of E. coli orthologs
2,557
Number of proteins having E. coli orthologs
2,175
 
(39% of the proteome)
Total number of K. pneumoniae homologs
37,430
Number of proteins having K. pneumoniae homologs
3,527
 
(63.3% of the proteome)
Total number of K. pneumoniae orthologs
2,778
Number of proteins having K. pneumoniae orthologs
2,372
 
(42.6% of the proteome)
Total number of S. maltophilia homologs
21,690
Number of proteins having S. maltophilia homologs
3,385
 
(60.8% of the proteome)
Total number of S. maltophilia orthologs
2,412
Number of proteins having S. maltophilia orthologs
2,147
 
(38.5% of the proteome)

Structural Biology

Number of P. aeruginosa structures (unique chains)
1,727
Number of P. aeruginosa structures (unique PDBs)
623
Number of P. aeruginosa proteins having structure
281
 
(5% of the proteome)
Total number of homologs in PDB (unique chains)
262,453
Total number of homologs in PDB (unique PDBs)
25,720
Number of proteins having PDB homologs
3,453
 
(62% of the proteome)
Number of proteins with XtalPred annotations
5,567
 
(99.9% of the proteome)
Number of residues with XtalPred annotations
1,861,267