Welcome to the Aeropath Target Database. This resource aims to aid the prioritization of targets from the genome of Pseudomonas aeruginosa as part of the EU-funded AEROPATH project.
Pseudomonas aeruginosa is a common Gram negative bacterium which acts as an opportunistic pathogen causing pneumonia, septic shock, urinary tract and gastrointestinal infections. It is a particular problem for burns victims and Cystic Fibrosis patients and is increasingly exhibiting worrying antibiotic resistance.
The Aeropath Target Database aids the identification of potential drug targets from the genome of Pseudomonas aeruginosa by coupling a chemistry-led approach to predicting target druggability with information on gene essentiality, virulence factors, predicted selectivity, related bacterial orthologs and assessment of structural biology accessibility.
Our approach is to integrate information on each of these criteria to enable a rational assessment, at genome-scale, the suitability of each potential Pseudomonas aeruginosa target for drug discovery.